News & Publications Press Releases Featured Nov 4, 2025 Press Release Syndeio Biosciences Appoints Aaron Koenig, M.D., as Chief Medical Officer Nov 4, 2025 Press Release Nov 4, 2025 Press Release May 27, 2025 Press Release Syndeio Biosciences Launches to Lead the Emerging Field of Synapse-Targeted Neurotherapeutics May 27, 2025 Press Release May 27, 2025 Press Release Feb 19, 2025 Press Release Gate Neurosciences Strengthens Focus on the Synapse as a Therapeutic Target with Acquisition of Boost Neuroscience Feb 19, 2025 Press Release Feb 19, 2025 Press Release Dec 12, 2024 Press Release Gate Neurosciences Presents New Data and Insights Highlighting Unique Pharmacology of Synaptic Function Modulators at the 2024 ACNP Annual Meeting Dec 12, 2024 Press Release Dec 12, 2024 Press Release Dec 3, 2024 Press Release Gate Neurosciences and University of Pittsburgh Collaborate to Initiate Phase 2 Trial Combining Apimostinel with Digital Therapeutic for Depression Dec 3, 2024 Press Release Dec 3, 2024 Press Release May 15, 2024 Press Release Gate Neurosciences to share new data and research on its synaptic function molecules with multiple posters at 2024 ASCP meeting May 15, 2024 Press Release May 15, 2024 Press Release Publications Featured Jan 24, 2025 Publication Demystifying the Antidepressant Mechanism of Action of Stinels, a Novel Class of Neuroplastogens: Positive Allosteric Modulators of the NMDA Receptor Jan 24, 2025 Publication Donello (2025) Jan 24, 2025 Publication Jan 4, 2024 Publication Targeting metaplasticity mechanisms to promote sustained antidepressant actions Jan 4, 2024 Publication Gould (2024) Jan 4, 2024 Publication Mar 3, 2023 Publication Aprison Lecture - Novel Approach to NMDA Modulation, Plasticity, Rapid Antidepressant Drugs Mar 3, 2023 Publication Shekhar (2023) Mar 3, 2023 Publication Jan 3, 2023 Publication NMDA Receptor Activation-Dependent Antidepressant-Relevant Behavioral and Synaptic Actions of Ketamine Jan 3, 2023 Publication Zanos (2023) Jan 3, 2023 Publication Dec 12, 2022 Publication Zelquistinel Is an Orally Bioavailable Novel NMDA Receptor Allosteric Modulator That Exhibits Rapid and Sustained Antidepressant-Like Effects Dec 12, 2022 Publication Donello (2022) Dec 12, 2022 Publication Oct 15, 2020 Publication Positive modulation of NMDA receptors by AGN-241751 exerts rapid antidepressant-like effects via excitatory neurons Oct 15, 2020 Publication Duman (2020) Oct 15, 2020 Publication
