News & Publications Press Releases Featured November 4, 2025 Press Release Syndeio Biosciences Appoints Aaron Koenig, M.D., as Chief Medical Officer November 4, 2025 Press Release Read more → November 4, 2025 Press Release May 27, 2025 Press Release Syndeio Biosciences Launches to Lead the Emerging Field of Synapse-Targeted Neurotherapeutics May 27, 2025 Press Release Read more → May 27, 2025 Press Release February 19, 2025 Press Release Gate Neurosciences Strengthens Focus on the Synapse as a Therapeutic Target with Acquisition of Boost Neuroscience February 19, 2025 Press Release Read more → February 19, 2025 Press Release December 12, 2024 Press Release Gate Neurosciences Presents New Data and Insights Highlighting Unique Pharmacology of Synaptic Function Modulators at the 2024 ACNP Annual Meeting December 12, 2024 Press Release Read more → December 12, 2024 Press Release December 3, 2024 Press Release Gate Neurosciences and University of Pittsburgh Collaborate to Initiate Phase 2 Trial Combining Apimostinel with Digital Therapeutic for Depression December 3, 2024 Press Release Read more → December 3, 2024 Press Release May 15, 2024 Press Release Gate Neurosciences to share new data and research on its synaptic function molecules with multiple posters at 2024 ASCP meeting May 15, 2024 Press Release Read more → May 15, 2024 Press Release Publications Featured January 24, 2025 Publication Demystifying the Antidepressant Mechanism of Action of Stinels, a Novel Class of Neuroplastogens: Positive Allosteric Modulators of the NMDA Receptor January 24, 2025 Publication Donello (2025) Read more → January 24, 2025 Publication January 4, 2024 Publication Targeting metaplasticity mechanisms to promote sustained antidepressant actions January 4, 2024 Publication Gould (2024) Read more → January 4, 2024 Publication March 3, 2023 Publication Aprison Lecture - Novel Approach to NMDA Modulation, Plasticity, Rapid Antidepressant Drugs March 3, 2023 Publication Shekhar (2023) Read more → March 3, 2023 Publication January 3, 2023 Publication NMDA Receptor Activation-Dependent Antidepressant-Relevant Behavioral and Synaptic Actions of Ketamine January 3, 2023 Publication Zanos (2023) Read more → January 3, 2023 Publication December 12, 2022 Publication Zelquistinel Is an Orally Bioavailable Novel NMDA Receptor Allosteric Modulator That Exhibits Rapid and Sustained Antidepressant-Like Effects December 12, 2022 Publication Donello (2022) Read more → December 12, 2022 Publication October 15, 2020 Publication Positive modulation of NMDA receptors by AGN-241751 exerts rapid antidepressant-like effects via excitatory neurons October 15, 2020 Publication Duman (2020) Read more → October 15, 2020 Publication
